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Immune System (Allergen Exposure)
- Molecular classification
- Immune System Process
01
Overview
The immune system's response to allergen exposure is a complex process involving sensitization and effector phases. Sensitization involves IgE production and mast cell priming. Re-exposure triggers mast cell degranulation, releasing inflammatory mediators. Therapeutic strategies aim to block these mediators or induce tolerance through immunotherapy. Dysregulation of the immune system underlies all allergic diseases.
- Other names
- Allergic ResponseAllergen-induced Immune ResponseType I Hypersensitivity
02
Mechanism of action
Varied, depending on the specific drug; includes blocking histamine receptors, suppressing inflammation, preventing IgE binding, and inducing immune tolerance.
03
Biological functions
Immune responseInflammationHypersensitivityTolerance induction
04
Disease associations
Allergic rhinitisAsthmaFood allergyAtopic dermatitisAnaphylaxis
05
Safety considerations
Anaphylaxis (during allergen immunotherapy)Side effects of corticosteroids (e.g., immunosuppression, bone loss)Rebound symptoms after stopping treatmentDevelopment of new allergies
06
Interacting drugs
Antihistamines
4 more in the full profile.
07
Biomarkers
Allergen-specific IgE levelsTotal IgE levelsEosinophil countBasophil activation markersT cell cytokine profiles (e.g., IL-4, IL-5, IL-13)IL-10 levelsSpecific IgG4 levels after immunotherapy
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