Immune System (Chimerism Induction)

Chimerism induction in the immune system is a therapeutic strategy aimed at establishing a state of coexistence between donor and recipient hematopoietic cells, primarily to induce immune tolerance and prevent graft rejection in transplantation. This involves creating mixed chimerism where both donor and recipient immune systems interact to promote long-term tolerance, often through mechanisms such as clonal deletion, anergy, and regulatory T cell activity. Various methods, including hematopoietic stem cell transplantation and combined organ/bone marrow transplantation, are used to achieve this goal. Clinical applications focus on reducing or eliminating the need for chronic immunosuppression in transplant recipients.

Other names

Chimerism-based ImmunotherapyTransplantation Tolerance InductionHematopoietic Stem Cell Transplantation for ToleranceMixed Chimerism

Induction of donor-recipient hematopoietic chimerism leading to central and peripheral immune tolerance to donor antigens.