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Immune System (Desensitization) (None)
- Target
- None
- Molecular classification
- Other
01
Overview
Immune system desensitization refers to a therapeutic process designed to reduce or eliminate hypersensitivity reactions by gradually retraining the immune system to tolerate specific allergens or antigens. This is most commonly applied in the context of allergies, autoimmune diseases, and certain transplant protocols. It involves repeated exposure to increasing doses of the allergen to shift the immune response from IgE to IgG4/IgA and induce regulatory T cells.
02
Mechanism of action
Gradual exposure to allergen leading to increased IgG4/IgA production and Treg cell expansion.
03
Biological functions
Immune responseRegulation of allergic responseInduction of tolerance
04
Disease associations
AllergyAutoimmunityTransplant rejection
05
Safety considerations
AnaphylaxisLocal injection site reactionsExacerbation of allergic symptomsPotential for delayed reactions
06
Interacting drugs
Allergen extracts
1 more in the full profile.
07
Biomarkers
Allergen-specific IgE levelsAllergen-specific IgG4 levelsRegulatory T cell (Treg) countsCytokine profiles (IL-10, TGF-β)
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