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Target intelligence / Profile preview
Immune System (Desensitization to Specific Allergens) (AIT)
- Target
- AIT
- Molecular classification
- Immune System Process, Therapeutic Intervention
01
Overview
Desensitization to specific allergens, or allergen-specific immunotherapy (AIT), is a medical treatment designed to reduce allergic reactions by gradually training the immune system to tolerate specific allergens. This involves changes in mast cell/basophil activity, T cell populations (increased Tregs), and B cell antibody production (IgE to IgG4/IgA shift).
- Other names
- Allergen-specific ImmunotherapyAllergy DesensitizationAllergy Immunotherapy
02
Mechanism of action
Gradual exposure to allergen to induce tolerance through shifts in immune cell populations and antibody production. Key mechanisms include: 1) early mast cell/basophil desensitization, 2) expansion of regulatory T cells (Tregs), 3) decreased IgE and increased IgG4/IgA production.
03
Biological functions
Immune Response ModulationTolerance InductionSuppression of Allergic Reactions
04
Disease associations
Allergic DiseasesAsthmaRhinitisAnaphylaxis
05
Safety considerations
Anaphylaxis (risk of allergic reaction during treatment)Local injection site reactions (SCIT)Gastrointestinal side effects (OIT)Exacerbation of allergic symptoms
06
Interacting drugs
Allergen Extracts (Subcutaneous)
1 more in the full profile.
07
Biomarkers
Allergen-specific IgE levelsAllergen-specific IgG4 levelsRegulatory T cell (Treg) frequencyCytokine profiles (IL-10, TGF-beta)
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