Target intelligence / Profile preview

Immune System (Desensitization via Allergen-Specific Immunotherapy) (N/A)

Target: N/A
Molecular classification: N/A - This is a system, not a molecule

Overview

Allergen-specific immunotherapy (desensitization) is a medical intervention aimed at reducing or eliminating allergic responses by retraining the immune system to tolerate specific allergens. This involves controlled exposure to increasing doses of the allergen, leading to immunological changes such as increased IgG4 and regulatory T cell activity, ultimately reducing allergic reactions upon natural exposure.

Other names: Allergen-specific immunotherapyDesensitization therapy

Mechanism of action

Induction of tolerance through repeated controlled exposure to allergens, leading to increased IgG4 and Treg activity, and decreased IgE and Th2 activity.

Biological functions

Immune response modulationInduction of toleranceSuppression of allergic reactions

Disease associations

Allergic rhinitisAsthmaConjunctivitisInsect venom allergyFood allergies

Safety considerations

AnaphylaxisLocal injection site reactionsExacerbation of allergic symptoms

Interacting drugs

Allergen extracts (pollen, dust mites, pet dander, grass/tree pollen, peanut/milk/nuts)

2 more in the full profile.

Biomarkers

Allergen-specific IgE levelsAllergen-specific IgG4 levelsTreg cell populations (FOXP3+ CD4+CD25+ Tregs, Tr1 cells)

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