Immune system (desensitization via exposure to *Ambrosia artemisiifolia* allergens)

The immune system's response to desensitization involves controlled exposure to *Ambrosia artemisiifolia* allergens, aiming to retrain the immune system and reduce or eliminate allergic symptoms over time. This process involves shifting the immune response from a Th2-mediated inflammatory state to a more tolerant state through the induction of regulatory T cells and blocking IgG4 antibodies. The primary target allergens are proteins found in ragweed pollen, with Amb a 1 being the most prevalent and clinically relevant.

Other names

Allergen-specific immunotherapy (AIT) for ragweed allergyRagweed allergy desensitizationAmbrosia artemisiifolia immunotherapy

Induction of immune tolerance through repeated controlled antigen exposure, shifting the immune response from Th2-mediated inflammation to T regulatory cell-mediated suppression and IgG4 antibody production.