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Target intelligence / Profile preview
Immune System (Desensitization via Specific IgE Modulation) (N/A)
- Target
- N/A
- Molecular classification
- Immune System, IgE Antibody, FcεRI Receptor
01
Overview
Desensitization via specific IgE modulation targets the immune system's allergic response, particularly by altering the production and function of allergen-specific Immunoglobulin E (IgE). This approach is central to allergen immunotherapy (AIT) and biologic treatments for allergic diseases. The goal is to reduce hypersensitivity reactions by modulating IgE levels, its receptor interactions, and downstream immune signaling.
- Other names
- Allergen Immunotherapy TargetIgE ModulationAllergy DesensitizationSpecific IgE Reduction
02
Mechanism of action
Reduction/inhibition/modification of specific-IgEs' ability to trigger effector cell degranulation
03
Biological functions
Immune response modulationAllergen-specific IgE productionMast cell activationBasophil activationT cell regulationB cell regulationAntibody production
04
Disease associations
Allergic rhinitisAllergic conjunctivitisAsthmaFood allergyAtopic dermatitisAnaphylaxis
05
Safety considerations
Anaphylaxis (during allergen immunotherapy)Injection site reactionsIncreased risk of infections (with some biologics)Potential for rebound effects after discontinuation of therapy
06
Interacting drugs
Omalizumab
2 more in the full profile.
07
Biomarkers
Allergen-specific IgE levelsTotal IgE levelsAllergen-specific IgG4 levelsMast cell activation markersBasophil activation markersT cell cytokine profiles (e.g., IL-4, IL-5, IL-10, IFN-gamma)
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