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Target intelligence / Profile preview
Immune system (IgE-mediated allergy)
- Molecular classification
- Signaling pathway, Immune pathway
01
Overview
The IgE-mediated allergy pathway is a hypersensitivity reaction in which the immune system overreacts to harmless substances (allergens) by producing allergen-specific IgE antibodies. These IgE antibodies bind to high-affinity FcεRI receptors on mast cells and basophils, leading to rapid degranulation and release of inflammatory mediators upon re-exposure to the allergen, causing acute allergic symptoms. Strategies targeting this pathway include anti-IgE monoclonal antibodies that block IgE binding or therapies modifying glycosylation patterns on circulating IgEs.
02
Mechanism of action
Blocking IgE binding to FcεRI receptor, preventing mast cell degranulation, reducing Th2 response.
03
Biological functions
Immune responseInflammationHypersensitivity
04
Disease associations
Allergic diseasesAnaphylaxisAsthmaAtopic dermatitisFood allergyAllergic rhinitis
05
Safety considerations
Anaphylaxis (paradoxical reaction to anti-IgE therapy)Injection site reactionsIncreased risk of certain infections (rare)
06
Interacting drugs
Anti-IgE monoclonal antibodies (e.g., Omalizumab)
3 more in the full profile.
07
Biomarkers
Allergen-specific IgE levelsTotal IgE levelsEosinophil countMast cell activation markers (e.g., tryptase)
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