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Target intelligence / Profile preview
Immune system (IgE-mediated response) (IgE-mediated response)
- Target
- IgE-mediated response
- Molecular classification
- Immune pathway
01
Overview
The IgE-mediated immune response is a specialized arm of the immune system primarily involved in defense against parasitic infections and in the pathogenesis of allergic diseases. Immunoglobulin E (IgE) is an antibody produced by plasma cells, and it plays a central role in type I hypersensitivity reactions, which include common allergies such as food allergies, asthma, allergic rhinitis, and anaphylaxis.
- Other names
- IgE pathwayType I hypersensitivityAllergic response
02
Mechanism of action
Various, depending on the drug. Antihistamines block histamine receptors. Epinephrine reverses vasodilation and bronchoconstriction. Corticosteroids suppress inflammation. Omalizumab binds to IgE, preventing it from binding to mast cells and basophils. Mast cell stabilizers prevent degranulation.
03
Biological functions
Immune responseDefense against parasitic infectionsAllergic reactionInflammation
04
Disease associations
Allergic diseasesAsthmaFood allergiesAllergic rhinitisAnaphylaxisParasitic infections
05
Safety considerations
AnaphylaxisImmunosuppression (with corticosteroids)Side effects of antihistamines (e.g., drowsiness)Potential for severe reactions to allergens
06
Interacting drugs
Antihistamines
4 more in the full profile.
07
Biomarkers
Serum IgE levelsAllergen-specific IgE levelsEosinophil countMast cell activation markers
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