Immune System (Induction of Tolerance to Ambrosia artemisiifolia Allergens) (N/A)

The immune system, in the context of tolerance induction to *Ambrosia artemisiifolia* allergens, refers to the network of cells and molecular pathways that can be modulated to reduce or eliminate allergic responses through immunological tolerance. This process is central to allergen immunotherapy (AIT), which aims to desensitize individuals who are allergic to ragweed pollen by shifting their immune response from a pathogenic, allergy-promoting state toward a tolerant, non-reactive state. Key mechanisms involve the shift from Th2 dominance to Treg-mediated regulation, increased production of blocking antibodies (IgG4), and decreased IgE responses to Amb a 1, the major ragweed allergen.

Other names

Immune ToleranceAllergen Immunotherapy (AIT)Desensitization to Ragweed AllergensTolerance induction in Ragweed Allergy

Shift from Th2-mediated allergy to regulatory/tolerant profile through repeated exposure to allergen extracts leading to increased Treg activity, blocking antibody production (IgG4), and reduced IgE response.