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Immune System (Induction of Tolerance via Exposure to Ambrosia artemisiifolia Allergens)
- Molecular classification
- Immune system, Regulatory pathways
01
Overview
The immune system can be modulated to induce tolerance to Ambrosia artemisiifolia (common ragweed) allergens through allergen-specific immunotherapy (AIT). This process retrains the immune system to avoid a pathological response upon exposure to ragweed pollen. AIT involves gradual administration of increasing allergen doses to promote regulatory pathways over inflammatory ones.
- Other names
- Allergen-specific immunotherapy (AIT)Ragweed allergy immunotherapyImmune tolerance induction to Ambrosia artemisiifolia
02
Mechanism of action
Allergen-specific immunotherapy induces regulatory pathways involving dendritic cells and regulatory T cells, leading to reduced reactivity to ragweed allergens. IL-10 and TGF-β contribute to the maintenance of tolerance.
03
Biological functions
Immune response modulationTolerance inductionPrevention of hypersensitivityRegulation of inflammatory pathways
04
Disease associations
Allergic rhinitis (hay fever)Ambrosia artemisiifolia allergy
05
Safety considerations
Local injection site reactions (for subcutaneous AIT)Systemic allergic reactions (anaphylaxis)Exacerbation of asthma
06
Interacting drugs
Ragweed pollen extracts (subcutaneous)
1 more in the full profile.
07
Biomarkers
IgE levels to Amb a 1, Amb a 3, Amb a 4, etc.Regulatory T cell (Treg) frequencyCytokine production (IL-10, TGF-β)
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