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Target intelligence / Profile preview
Immune System Activation via Viral Infection of Tumor Cells
- Molecular classification
- Biological process, Immunotherapy
01
Overview
Immune system activation via viral infection of tumor cells refers to the process by which viruses—either naturally occurring or genetically engineered (oncolytic viruses)—infect and replicate within cancer cells, leading to both direct tumor cell lysis and the stimulation of robust anti-tumor immune responses. This approach leverages the body's natural antiviral defense mechanisms to recognize, attack, and eliminate malignant cells.
- Other names
- Oncolytic VirotherapyViral ImmunotherapyTumor-selective viral therapy
02
Mechanism of action
Viral infection → oncolysis → release/presentation TAAs/DAMPs → innate/adaptive immunity
03
Biological functions
Immune responseCell deathAntiviral defenseTumor cell lysisAntigen presentation
04
Disease associations
Cancer
05
Safety considerations
Pre-existing antiviral immunityOff-target viral infectionCytokine release syndromeTumor microenvironment suppression
06
Interacting drugs
Talimogene laherparepvec (T-VEC)
1 more in the full profile.
07
Biomarkers
Tumor-associated antigens (TAAs)PD-L1 expressionCD8+ T-cell infiltrationInterferon signaling pathway activity
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