Immune system cell in skin

"Immune system cells in the skin" is not a specific molecular target or receptor but rather refers to a diverse population of cells that mediate both innate and adaptive immunity within the cutaneous environment. These include keratinocytes, dendritic cells (such as Langerhans cells and dermal dendritic cells), macrophages, T lymphocytes (including resident memory T cells and regulatory T cells), B lymphocytes, natural killer (NK) cells, neutrophils, and mast cells[3][1][4]. Each subset has distinct roles: Keratinocytes form the first line of defense by expressing pattern-recognition receptors like Toll-like receptors to detect pathogens[3]. Dendritic cells—including Langerhans and dermal dendritic populations—are key antigen-presenting cells that initiate adaptive responses[1][5]. Macrophages provide phagocytic clearance and orchestrate inflammation[3]. T lymphocytes mediate cellular immunity; subsets such as Th17/Th22 are implicated in inflammatory diseases like psoriasis[3]. B lymphocytes produce antibodies for humoral immunity. These populations collectively protect against infection, maintain tolerance to harmless antigens, regulate inflammation, and contribute to pathologies such as chronic inflammatory diseases or cancer when dysregulated. Because "immune system cell in skin" is not a single molecule or defined therapeutic target but an umbrella term for many different cellular types with varied functions and markers[2], it does not fit standard drug-target classification schemes.

Other names

Skin immune cellCutaneous immune cellResident immune cell of the skin