Immune System Desensitization via Gradual Allergen Exposure

Immune system desensitization via gradual allergen exposure, also known as allergen immunotherapy or exposure therapy, is a medical approach designed to reduce or eliminate allergic reactions by gradually introducing increasing amounts of an allergen to which a person is sensitive. This process aims to retrain the immune system to become less reactive or non-responsive (tolerant) to the specific allergen over time. It involves controlled antigen presentation over time, leading to changes in antibody profiles and regulatory T cell activity.

Other names

Allergen immunotherapyAllergy shotsOral Immunotherapy (OIT)Sublingual ImmunotherapyExposure therapy

Gradual introduction of increasing allergen doses to shift immune response from IgE-mediated allergy to tolerance through changes in antibody profiles and regulatory T cell activity.