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Immune System Modulation via Induction of Regulatory T Cells and Shift from Th2 to Th1 Response (Treg/Th1 Modulation)
- Target
- Treg/Th1 Modulation
- Molecular classification
- Cytokine signaling modulation, T cell differentiation, Immune checkpoint modulation
01
Overview
Strategies to modulate the immune system by inducing regulatory T cells (Tregs) and shifting the balance of helper T cell responses from a Th2-dominated profile to a Th1-dominated profile. This approach aims to restore immune homeostasis, suppress autoimmunity, improve responses to intracellular pathogens, and modulate allergic reactions. Key components include Treg induction/expansion and manipulating cytokine signaling pathways to favor Th1 differentiation.
- Other names
- Treg Induction and Th1 PolarizationRegulatory T Cell Expansion and Th2/Th1 ShiftImmune Tolerance InductionTh2 to Th1 Shift
02
Mechanism of action
Induction or expansion of regulatory T cells, shift from Th2 to Th1 response via cytokine modulation and signaling pathway activation.
03
Biological functions
Immune suppressionImmune toleranceT cell differentiationCytokine productionInflammation regulation
04
Disease associations
Autoimmune diseasesAllergic diseasesInfectious diseasesCancerInflammation
05
Safety considerations
Increased risk of infection due to immune suppressionPotential for tumor development if Tregs suppress anti-tumor immunityCytokine storm if Th1 response is excessively stimulatedAutoimmunity if tolerance is broken by Th1 stimulation
06
Interacting drugs
IL-2
4 more in the full profile.
07
Biomarkers
Foxp3 expressionCD25 expressionIL-10 levelsTGF-beta levelsIFN-gamma levelsIL-4 levelsTh1/Th2 cytokine ratio
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