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Target intelligence / Profile preview
Immune system modulation via induction of tolerance to Betula verrucosa allergens
- Molecular classification
- Other
01
Overview
This target refers broadly to strategies that retrain the immune system—primarily through specific immunotherapies—to tolerate Betula verrucosa allergens like Bet v 1. This involves complex interactions between antigen-presenting dendritic cells and various subsets of helper/regulatory T-cells leading ultimately toward reduced allergic reactivity through enhanced regulation rather than simple desensitization.
- Other names
- Birch pollen immunotherapyBet v 1 tolerance induction
02
Mechanism of action
Induction of regulatory T cell responses, shift from Th2-dominated immunity
03
Biological functions
Immune responseTolerance induction
04
Disease associations
Allergy
05
Safety considerations
AnaphylaxisLocal injection site reactions
06
Interacting drugs
Birch pollen extracts
1 more in the full profile.
07
Biomarkers
Bet v 1-specific IgE levelsIL-10 productionTr1 cell frequency
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