Immune System Modulation via Induction of Tolerance to Specific Grass Pollens (Grass Pollen IT)

Induction of immune tolerance to specific grass pollens is mediated by expansion and activation of regulatory T cell subsets—primarily those producing IL‑10 and/or TGF‑β—alongside shifts in antibody profiles favoring non-inflammatory subclasses. These changes collectively suppress allergic inflammation at both systemic and mucosal sites following exposure or therapy with relevant allergens. This multi-faceted modulation forms the mechanistic basis for current—and future—immunotherapeutic strategies against seasonal allergies due to grass pollens.

Other names

Allergen-specific immunotherapy for grass pollen allergyTolerance induction to grass pollenGrass pollen immunotherapy

Expansion of regulatory T cells, cytokine modulation (increased IL-10/TGF-β), antibody class switching (IgE to IgG4/IgA)