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Target intelligence / Profile preview
Immune System Modulation via Total Skin Electron Beam Irradiation (None)
- Target
- None
- Molecular classification
- Radiotherapy, Immune modulator
01
Overview
Total skin electron beam irradiation (TSEBI) is a radiotherapy technique that modulates the immune system through DNA damage, DAMP release, and cytokine production. While primarily used for cutaneous lymphomas like mycosis fungoides, TSEBI can enhance anti-tumor immunity and potentially synergize with immunotherapies. However, it also carries risks, including acute toxicities and heightened infection susceptibility due to compromised skin integrity. The balance between therapeutic benefit and adverse effects on immunity is crucial.
- Other names
- TSEBITSEBTTotal Skin Electron Beam TherapyWhole Body Irradiation
02
Mechanism of action
Induction of DNA damage leading to immunogenic cell death, DAMP release, cytokine modulation, and activation of immune cells.
03
Biological functions
Immune response modulationCell death inductionCytokine productionNF-κB pathway activationAntigen presentation enhancement
04
Disease associations
Cutaneous T-cell lymphomaMycosis fungoidesCancer therapy
05
Safety considerations
Erythema/desquamationBlistersHyperpigmentationPainSecondary infectionsImmunosuppressionPotential for cytokine stormLong-term risk of secondary malignancies
06
Interacting drugs
Checkpoint inhibitors
5 more in the full profile.
07
Biomarkers
Cytokine levels (TNFα, IL-6, IL-1β)MHC class I expression on tumor cellsDAMP levelsImmune cell populations (dendritic cells, cytotoxic T-cells, MDSCs, Tregs)
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