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Target intelligence / Profile preview
Immune system modulation via type I interferon receptor signaling pathway
- Molecular classification
- Signaling pathway
01
Overview
The type I interferon (IFN) receptor signaling pathway is a critical mechanism by which the immune system detects and responds to viral infections and other immune challenges. This pathway is initiated when type I interferons bind to their common cell surface receptor complex known as the type I interferon receptor (IFNAR), which consists of two subunits: IFNAR1 and IFNAR2. Upon binding of a type I interferon ligand, intracellular kinases JAK1 and TYK2 are activated, leading to phosphorylation of STATs and subsequent transcriptional activation of hundreds of interferon-stimulated genes (ISGs) that mediate antiviral defense, immunomodulation, apoptosis regulation, and anti-proliferative effects.
02
Mechanism of action
Activation of JAK-STAT signaling pathway leading to transcription of interferon-stimulated genes (ISGs).
03
Biological functions
Signal transductionImmune responseAntiviral defenseCell proliferation regulationApoptosis regulationImmunomodulation
04
Disease associations
Viral infectionsAutoimmune diseasesCancer
05
Safety considerations
Chronic overactivation leading to autoimmunityImmune exhaustionPathological inflammation
06
Interacting drugs
Recombinant type I interferons
2 more in the full profile.
07
Biomarkers
Expression levels of ISGsLevels of type I interferons
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