Immune system response modulation

"Immune system response modulation" refers to strategies and interventions aimed at altering the activity of the immune system to achieve therapeutic benefit. This can involve enhancing an underactive immune response (as in cancer immunotherapy) or suppressing an overactive one (as in autoimmune diseases). Approaches include manipulating cytokines and chemokines; targeting co-stimulatory molecules such as CD40/CD40L; using monoclonal antibodies against checkpoints; modifying cellular metabolism; and employing gene editing tools. These interventions act on various molecular targets within complex networks that regulate immunity but do not represent a single molecule or receptor themselves. Therefore, "immune system response modulation" is not considered a canonical therapeutic target but rather describes a class of therapeutic strategies involving multiple distinct molecular entities across diverse biological pathways.[1][2][3][4]

Other names

Immune modulationImmunomodulationModulation of immune responseImmune system modulation