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Immune System Tolerance Induction via Dermatophagoides farinae and Dermatophagoides pteronyssinus Allergens
- Molecular classification
- Immunological Process, Allergen Immunotherapy, Immune Tolerance
01
Overview
The process of inducing immune tolerance through controlled exposure to allergens from Dermatophagoides farinae and Dermatophagoides pteronyssinus. This involves shifting the immune response from a Th2-dominated allergic profile toward a more regulated state, characterized by expansion of allergen-specific regulatory T cells, increased IgG4 production, and suppression of IgE and Th2 cytokines.
- Other names
- Dust Mite Allergen ImmunotherapyDermatophagoides farinae/pteronyssinus AITHouse Dust Mite Tolerance Induction
02
Mechanism of action
Repeated exposure to mite allergens promotes regulatory T cell development, induces IgG4 blocking antibodies, and suppresses IgE production, leading to tolerance.
03
Biological functions
Immune response modulationAllergen desensitizationRegulatory T cell inductionIgG4 productionTh2 suppression
04
Disease associations
Allergic rhinitisAsthmaAtopic dermatitisDust mite allergy
05
Safety considerations
AnaphylaxisLocal injection site reactionsExacerbation of allergic symptomsRisk of systemic reactions
06
Interacting drugs
Dermatophagoides farinae extract
3 more in the full profile.
07
Biomarkers
Allergen-specific IgE levelsAllergen-specific IgG4 levelsFoxP3+ T cell frequencyIL-10 productionTGF-β productionTh2 cytokine levels (IL-4, IL-5, IL-13)
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