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Target intelligence / Profile preview
Immune Tolerance Induction via Dermatophagoides pteronyssinus Allergens (None)
- Target
- None
- Molecular classification
- Immune System Process, Allergen Immunotherapy
01
Overview
Immune tolerance induction in response to exposure to allergens from Dermatophagoides pteronyssinus (house dust mite). This process is central to allergen immunotherapy, which aims to retrain the immune system and reduce allergic responses. Key players include dendritic cells, regulatory T cells, and cytokines like IL-10 and TGF-β. Successful immunotherapy leads to increased IgG4/IgA, decreased IgE, a shift from Th2 to Th1 immunity, and expansion of Tregs, collectively dampening hypersensitivity reactions.
02
Mechanism of action
Induction/expansion of regulatory T cells (Tregs) secreting IL-10/TGF-β; Shift from Th2-dominated immunity to Th1-skewed profiles; Increased production of blocking antibodies (IgG4/IgA); Decreased IgE production
03
Biological functions
Immune toleranceRegulation of immune responseAntigen presentationCytokine productionAntibody production
04
Disease associations
Allergic rhinitisAsthmaHouse dust mite allergy
05
Safety considerations
AnaphylaxisLocal injection site reactionsExacerbation of allergic symptoms
06
Interacting drugs
Dermatophagoides pteronyssinus allergen extracts (for immunotherapy)
07
Biomarkers
Increased IgG4/IgA levelsDecreased IgE levelsIncreased frequency of TregsChanges in Th1/Th2 cytokine ratios
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