Immunoglobulin E antibody recognizing shrimp tropomyosin allergen (IgE (shrimp tropomyosin-specific))

Immunoglobulin E (IgE) antibodies recognizing shrimp allergens, particularly tropomyosin (Pen a 1), are key mediators of shrimp allergy. These antibodies are produced by B cells in sensitized individuals and specifically bind to epitopes on shrimp tropomyosin, the major allergen in shrimp. Upon re-exposure to the allergen, IgE bound to FcεRI receptors on mast cells and basophils becomes cross-linked, triggering degranulation and release of histamine, leading to immediate-type allergic reactions including urticaria, angioedema, asthma, or anaphylaxis. The molecular basis of recognition involves specific amino acids, such as Glu98 in the IgE light chain, interacting with conserved residues on tropomyosin[1]. The diversity and heterogeneity of IgE responses among patients can affect severity and response to desensitization therapy[2]. Diagnostic and therapeutic strategies often target IgE or its interaction with mast cell receptors to manage allergic diseases.

Other names

IgE antibody specific for shrimp tropomyosinAllergen-specific IgE (shrimp)Tropomyosin-specific IgEAntibody to Pen a 1

Therapeutic antibodies (e.g., omalizumab) bind to free IgE, blocking its interaction with FcεRI, thus preventing mast cell degranulation and allergic symptoms