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Target intelligence / Profile preview
Immunoglobulin E-mediated Response (IgE-mediated Response)
- Target
- IgE-mediated Response
- Molecular classification
- Immune response
01
Overview
The immunoglobulin E (IgE)-mediated response is a specific type of immune reaction primarily involved in allergic diseases and defense against certain parasites. IgE is an antibody produced by plasma cells, a subset of B lymphocytes, in response to exposure to allergens or parasitic antigens. This response is central to the pathogenesis of immediate (Type I) hypersensitivity reactions, including allergic rhinitis, asthma, atopic dermatitis, food allergies, and anaphylaxis.
- Other names
- IgE responseType I hypersensitivity reactionImmediate hypersensitivity
02
Mechanism of action
Drugs target various points in the pathway including: - Blocking histamine effects - Suppressing inflammation - Blocking leukotriene-mediated effects - Preventing mast cell degranulation - Sequestering free IgE or blocking its receptor interaction
03
Biological functions
Allergic responseParasitic defenseImmune regulation
04
Disease associations
Allergic asthmaAllergic rhinitisAtopic dermatitisFood allergiesAnaphylaxisChronic urticaria
05
Safety considerations
Side effects of corticosteroids (long-term use)Anaphylaxis (paradoxically, in rare cases, with omalizumab)Immunosuppression (with corticosteroids)
06
Interacting drugs
Antihistamines
4 more in the full profile.
07
Biomarkers
Serum total IgEAllergen-specific IgE
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