Immunoglobulin E receptor-bound IgE (IgE-FcεRI complex)

Immunoglobulin E (IgE) receptor-bound IgE refers to the IgE antibody when it is bound to its high-affinity receptor, FcεRI, on the surface of mast cells and basophils. This complex plays a critical role in allergic reactions. When an allergen cross-links these receptor-bound IgE molecules, it triggers degranulation of mast cells and basophils, releasing histamine and other mediators responsible for allergic symptoms. FcεRI is a multi-subunit receptor with high affinity for IgE, primarily expressed on mast cells and basophils, but also found—though with different subunit composition—on other cells such as dendritic cells[1][2][3][5]. Therapeutic targeting often aims to disrupt the interaction between IgE and FcεRI to prevent allergic inflammation or to remove surface IgE to desensitize cells. This target is mechanistically distinct from IgE or FcεRI as individual molecules; it refers to the biologically essential functional complex that initiates the effector phase of allergic diseases and is thus a valid therapeutic target[2][3].

Other names

FcεRI-bound IgEIgE-FcεRI complexIgE antibody–FcεRI receptor complex

Blocking IgE binding to FcεRI (prevents receptor cross-linking and cell activation); Disrupting IgE–receptor interaction; Inhibiting downstream allergic inflammatory responses