Immunoglobulin E specific for Uro m 1 (sIgE (Uro m 1))

IgE antibodies specific for Uro m 1 are a subset of the Immunoglobulin E class that specifically recognize the Uro m 1 allergen, a major pollen protein from Urochloa mutica (Para grass) [1]. These antibodies are the primary mediators of Para grass-induced allergic diseases, such as allergic rhinitis and asthma, which are prevalent in tropical and subtropical regions [5]. In sensitized individuals, Uro m 1-specific IgE binds to high-affinity FcεRI receptors on mast cells and basophils; subsequent exposure to the allergen causes receptor cross-linking and the release of inflammatory mediators like histamine [2]. Therapeutic targeting of these antibodies involves the use of anti-IgE monoclonal antibodies like omalizumab, which sequester free IgE to prevent cellular activation, or allergen-specific immunotherapy (AIT) to modulate the immune response toward tolerance [4]. Monitoring levels of these specific antibodies is crucial for diagnosing grass pollen allergy and assessing the efficacy of therapeutic interventions [3]. The Uro m 1 protein itself belongs to the expansin family, which is characteristic of Group 1 grass allergens [1].

Other names

Anti-Uro m 1 IgEUro m 1-specific IgEPara grass-specific IgEImmunoglobulin E (Uro m 1)

Omalizumab is a recombinant humanized monoclonal antibody that selectively binds to the Cε3 domain of the IgE heavy chain. This binding sequesters free IgE and prevents its interaction with the high-affinity FcεRI receptor on the surface of mast cells and basophils, thereby inhibiting the release of inflammatory mediators during the allergic cascade [4].