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Target intelligence / Profile preview
Immunoglobulin epsilon Fc receptor (CD23)
- Target
- CD23
- Molecular classification
- C-type lectin receptor, Receptor
01
Overview
Immunoglobulin epsilon Fc receptor/CD23 is an essential regulator at the interface between humoral immunity and allergic inflammation—modulating both local cellular events through membrane-bound forms and systemic immunity through soluble variants. Its unique properties make it an attractive target for therapeutic modulation in allergy-related diseases. It regulates IgE responses, antigen presentation, and influences immune processes. Soluble forms of CD23 (sCD23) have cytokine-like activities. CD23 exists in two main isoforms: CD23a (B-cells) and CD23b (inducible via IL-4).
- Other names
- Fc epsilon RIIFcεRIILow-affinity IgE receptor
02
Mechanism of action
Targeting CD23 to modulate IgE-mediated allergic responses
03
Biological functions
Antigen presentationIgE regulationImmune modulationB-cell growth regulation
04
Disease associations
Allergic diseasesAsthmaAtopic dermatitisAllergic rhinitis
05
Safety considerations
Potential for broad immune modulationUnintended effects on B-cell function
06
Biomarkers
sCD23 levels in serum
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