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Target intelligence / Profile preview
Immunoglobulin G B Cell Receptor (IgG-BCR)
- Target
- IgG-BCR
- Molecular classification
- Receptor, Immunoglobulin, B Cell Receptor Complex
01
Overview
The Immunoglobulin G B cell receptor (IgG-BCR) is a membrane-bound form of immunoglobulin G that functions as the antigen recognition component of the B cell receptor complex on the surface of B lymphocytes. It plays a central role in adaptive immunity by recognizing specific antigens and initiating signaling cascades that lead to B cell activation, proliferation, and differentiation. The IgG-BCR consists of membrane-bound immunoglobulin G (mIgG) and signal transduction subunits (Ig-α/CD79A and Ig-β/CD79B). Upon antigen binding, the receptor triggers phosphorylation events within ITAMs on CD79A/B, leading to intracellular signaling cascades.
- Other names
- mIgG-BCRMembrane-bound IgG B cell receptorB cell receptor IgG
02
Biological functions
Antigen recognitionSignal transductionB cell activationAntigen internalizationAntigen presentationImmune response
03
Disease associations
AutoimmunityInfectionB cell lymphomasAllergy
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