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Target intelligence / Profile preview
Immunoglobulin G Heavy Chain (None)
- Target
- None
- Molecular classification
- Immunoglobulin, Antibody, Protein
01
Overview
The immunoglobulin G (IgG) heavy chain is a component of the IgG antibody molecule, which is the most abundant class of immunoglobulins in serum. It consists of a variable domain (VH) for antigen binding and three constant domains (CH1, CH2, CH3) that mediate effector functions. The heavy chain defines the IgG subclass (IgG1, IgG2, IgG3, IgG4), each with distinct biological properties. IgG antibodies play a crucial role in adaptive immunity by neutralizing pathogens, activating complement, and recruiting immune cells.
- Other names
- IgG Heavy ChainGamma Heavy ChainIGHG1IGHG2IGHG3IGHG4
02
Mechanism of action
Binding to target antigen, Fc-mediated effector functions (e.g., ADCC, CDC, phagocytosis), receptor blockade, signal modulation
03
Biological functions
Antigen bindingComplement activationFc receptor bindingADCC (Antibody-dependent cell-mediated cytotoxicity)OpsonizationImmune response
04
Disease associations
InfectionAutoimmunityInflammationCancer
05
Safety considerations
Infusion reactionsImmunogenicity (ADA formation)Off-target effectsCytokine release syndrome
06
Interacting drugs
Monoclonal antibodies
2 more in the full profile.
07
Biomarkers
IgG subclass levelsAnti-drug antibodies (ADA)
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