Immunoglobulin G receptor FCGRs

Immunoglobulin G receptors (Fc gamma receptors, or FcγRs) are a family of cell surface glycoproteins found on various immune cells. They play a central role in linking humoral and cellular immunity by binding to the Fc region of IgG antibodies and mediating diverse immune responses. They trigger effector functions in immune cells, including phagocytosis, antibody-dependent cellular cytotoxicity (ADCC), degranulation, cytokine production, antigen presentation, and regulation of inflammatory responses. Human classical FcγRs are divided into three main families: FcγRI (CD64), FcγRII (CD32), and FcγRIII (CD16). Polymorphisms in FCGR genes can impact susceptibility to autoimmune diseases, response to therapeutic antibodies, and infection risk.

Other names

Fc gamma receptorsFcγRsCD64CD32CD16

Modulation of immune cell activity through binding to IgG antibodies and triggering downstream signaling pathways.