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Immunoglobulin G receptor I (CD64)
- Target
- CD64
- Molecular classification
- Receptor, Integral membrane glycoprotein
01
Overview
CD64, also known as Fc gamma receptor I (FcγRI), is a high-affinity receptor for the Fc region of immunoglobulin G (IgG) antibodies. It is an integral membrane glycoprotein that plays a key role in immune responses, including phagocytosis, antigen presentation, and antibody-dependent cellular cytotoxicity (ADCC). Overactivation of CD64 can exacerbate autoimmune diseases, making it a target for therapeutic modulation. Its ability to bind monomeric therapeutic antibodies also makes it relevant for monoclonal antibody therapies.
- Other names
- Fc gamma receptor IFcγRICluster of Differentiation 64
02
Mechanism of action
Recruitment of effector functions, modulation of immune complex handling
03
Biological functions
PhagocytosisAntigen presentationAntibody-dependent cellular cytotoxicity (ADCC)Mediator secretion (cytokines/chemokines)Immune response
04
Disease associations
Bacterial infectionsAutoimmune diseasesCancer
05
Safety considerations
Off-target effects of therapeutic antibodiesExacerbation of autoimmune diseases
06
Interacting drugs
Therapeutic antibodies
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