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Target intelligence / Profile preview
Immunoglobulin G4 Antibody (IgG4)
- Target
- IgG4
- Molecular classification
- Immunoglobulin, Antibody
01
Overview
Immunoglobulin G4 (IgG4) is one of the four subclasses of human IgG antibodies. It exhibits unique structural and functional properties, including Fab-arm exchange, resulting in functionally monovalent antibodies. IgG4 acts primarily as a blocking antibody, inhibiting inflammatory responses and playing a role in allergy tolerance. Elevated levels are associated with autoimmune diseases and IgG4-related disease, making it a clinically relevant biomarker.
- Other names
- IgG subclass 4IgG4 antibody
02
Mechanism of action
N/A
03
Biological functions
Antigen bindingBlocking antibody activityImmune response modulationComplement activation (minimal)Fc receptor binding (minimal)
04
Disease associations
AllergyAutoimmunityRheumatoid arthritisIgG4-related diseasePemphigusBullous pemphigoidIdiopathic membranous glomerulonephritisMyasthenia gravis
05
Safety considerations
Potential for pathogenic autoantibody activityElevated levels may not always be indicative of disease
06
Biomarkers
Serum IgG4 levels (disease activity/severity in RA)Tissue IgG4-positive plasma cells (IgG4-related disease)
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