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Target intelligence / Profile preview
Immunoglobulin gamma Fc region receptor III-A (FcγRIIIa)
- Target
- FcγRIIIa
- Molecular classification
- Receptor, Transmembrane protein, Immunoglobulin superfamily
01
Overview
FcγRIIIa/CD16a is an activating receptor expressed primarily on NK cells, macrophages, and monocytes. It binds to the Fc region of IgG antibodies and triggers effector functions such as ADCC, phagocytosis, and cytokine release. Genetic variations and glycosylation patterns influence its affinity for IgG, impacting disease susceptibility and therapeutic outcomes with monoclonal antibodies.
- Other names
- CD16aFCGR3A
02
Mechanism of action
Activation of NK cells and macrophages via Fc region binding, leading to ADCC, phagocytosis, and cytokine production.
03
Biological functions
Antibody-dependent cellular cytotoxicity (ADCC)PhagocytosisCytokine releaseImmune complex clearanceImmune response
04
Disease associations
CancerAutoimmune diseasesInflammation
05
Safety considerations
Potential for cytokine release syndromeOff-target effects due to Fc receptor binding in non-cancerous tissuesVariability in response based on genetic polymorphisms
06
Interacting drugs
Therapeutic antibodies (e.g., Rituximab, Trastuzumab)
1 more in the full profile.
07
Biomarkers
FcγRIIIa-V158/F158 allotypeFcγRIIIa expression levels on NK cellsIgG binding affinity
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