Immunoglobulin heavy chain variable region V-II pseudogene

The **Ig heavy chain V-II pseudogene** is a segment of DNA highly homologous to functional immunoglobulin heavy chain variable region genes but has lost the ability to encode a functional protein due to disabling mutations such as premature stop codons or frameshifts[4][2]. Pseudogenes like this one are considered 'genomic fossils'—remnants of genes that may have had a function in ancestral species or earlier evolutionary stages, but are non-functional in modern humans[4][2]. They are not typically therapeutic targets as they lack protein expression and function and do not have known disease associations or drug interactions. While some pseudogenes can play regulatory roles at the RNA level (such as acting as microRNA sponges or generating non-coding RNAs with regulatory effects), for this specific pseudogene, no such function has been confirmed[8]. As a pseudogene of an immunoglobulin heavy chain variable region, it is catalogued mainly for genomic annotation, not for use as a drug target or disease biomarker.

Other names

Ig heavy chain V-II pseudogeneImmunoglobulin heavy variable (III)-5-2 (pseudogene)IGHV2 pseudogene