Immunoglobulin heavy constant alpha 2 (IGHA2)

Immunoglobulin heavy constant alpha 2 (IGHA2) encodes the constant region of the heavy chain of IgA2, a major subclass of Immunoglobulin A that plays a crucial role in mucosal immunity. IgA2 is secreted primarily at mucosal surfaces and acts as a first line of defense against pathogens. The protein forms part of the antibody structure, contributing to effector functions such as neutralization of pathogens and facilitating their clearance. IGHA2 exhibits structural polymorphisms and works in concert with other immunoglobulin components. Diseases associated with IGHA2 primarily relate to immune disorders and infection, and it may also be implicated as a marker in some hematological cancers[1][2][4][5][7]. Key points: - IGHA2 is *not* a classic drug target like a receptor or enzyme but is an essential component of the adaptive immune system. - There are no approved drugs that target IGHA2 itself; therapeutic relevance is as a biomarker rather than a drug target[2][4].

Other names

Ig alpha-2 chain C regionA2MImmunoglobulin alpha 2 (A2M marker)Constant region of heavy chain of IgA2Ig alpha-2 chain C region BUTIg alpha-2 chain C region LAN