Immunoglobulin heavy constant gamma P pseudogene (IGHGP)

IGHGP stands for Immunoglobulin heavy constant gamma P pseudogene. Located within the immunoglobulin heavy chain gene cluster on human chromosome 14, IGHGP is a non-functional genomic segment that resembles functional IGHG genes, which encode the constant regions of immunoglobulin gamma heavy chains (the main protein components of IgG antibodies)[1][2]. Pseudogenes like IGHGP may arise from gene duplication or retrotransposition events, leading to loss of protein-coding ability through frameshift mutations or premature stop codons. IGHGP does not encode a functional protein and does not contribute to immune system function, antibody formation, or therapeutic targeting[1][2]. It is sometimes referenced in genomic studies cataloging the full diversity of the immunoglobulin heavy chain locus but has no direct biological or clinical relevance.

Other names

Immunoglobulin heavy constant gamma pseudogeneIGHGP pseudogene