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Immunoglobulin heavy diversity 4-17 (IGHD4-17)
- Target
- IGHD4-17
- Molecular classification
- Other (Immunoglobulin gene segment, specifically a D (diversity) gene segment of the immunoglobulin heavy chain locus)
01
Overview
Immunoglobulin heavy diversity 4-17 (IGHD4-17) is one of the diversity (D) gene segments in the immunoglobulin heavy chain (IGH) locus on human chromosome 14, which contributes to antibody diversity through somatic V(D)J recombination in developing B cells[6][3][2]. The immunoglobulin heavy chain is formed by the recombination of variable (V), diversity (D), and joining (J) gene segments, resulting in each B cell expressing a unique antigen receptor[6][1]. IGHD4-17 encodes part of the variable domain in immunoglobulin heavy chains. While changes or polymorphism in the IGH locus broadly can influence immune function and susceptibility to disease, IGHD4-17 itself is a DNA sequence component and not a protein target, receptor, or enzyme, and it does not function as a direct therapeutic target or clinical biomarker[2][6][3].
- Other names
- IGHD417D4-17
02
Biological functions
Generation of immunoglobulin diversityV(D)J recombination in B cells
03
Disease associations
Other (Germline IGH variation affects antibody repertoire and, in turn, influences disease susceptibility and immune response, but IGHD4-17 itself has no direct, independent disease association)
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