Immunoglobulin heavy diversity 6-13 (IGHD6-13)

Immunoglobulin heavy diversity 6-13 (IGHD6-13) is a gene segment within the immunoglobulin heavy chain locus on human chromosome 14q32[5]. It falls within the "D" (diversity) segment class, which, together with V (variable) and J (joining) gene segments, undergoes somatic rearrangement during B-cell development to create the variable region of the antibody heavy chain, specifically contributing nucleotides to the hypervariable region CDR3[2][3]. This process allows the immune system to generate a vast antibody repertoire using a limited number of inherited gene segments[2][4]. IGHD segments themselves are not functional receptors, proteins, or therapeutic targets; rather, their rearrangement is necessary for the generation of functional immunoglobulin molecules. IGHD6-13 is one of many "D" gene segments, each providing genetic diversity crucial for immune recognition, but not known to be independently associated with specific diseases or targeted by drugs. Key points: - IGHD6-13 is not a standalone therapeutic target or receptor[2][3]. - Errors in naming and duplication in aliases ("DN1, DN1, IGHD613, IGHD6-13") indicate inconsistent use and potential mistakes in database entry[3]. - Its biological significance is limited to its contribution to immunoglobulin gene rearrangement and antibody diversity[2][4][5].

Other names

IGHD6-13IGHD613DN1