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Immunoglobulin heavy diversity 7-27 (IGHD7-27)
- Target
- IGHD7-27
- Molecular classification
- Other (Immunoglobulin gene segment: diversity (D) segment)
01
Overview
Immunoglobulin heavy diversity 7-27 (IGHD7-27) is a short DNA segment of the immunoglobulin heavy chain locus, located on chromosome 14 (14q32). It functions as one of several diversity (D) gene segments required for V(D)J recombination in developing B cells. During this process, IGHD7-27 can be randomly joined to variable (V) and joining (J) gene segments, contributing to the antigen-binding region of antibodies and thus helping to generate immune diversity. The proper rearrangement and combination of these gene segments underlie the immense variability of antibody specificities produced in humans. IGHD7-27 itself does not encode a protein or receptor, but is a genomic fragment integrated into mature immunoglobulin heavy chain genes following recombination.
- Other names
- IGHD727DHQ52
02
Biological functions
Immune responseGeneration of antibody diversitySomatic recombinationFormation of immunoglobulin hypervariable regions
03
Disease associations
Other (Indirect roles only; a gene segment essential for normal immunoglobulin formation; not itself associated directly with disease or therapeutic intervention)
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