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Immunoglobulin heavy diversity segment 5-24 (IGHD5-24)
- Target
- IGHD5-24
- Molecular classification
- Immunoglobulin gene segment, Other
01
Overview
Immunoglobulin heavy diversity 5-24 (IGHD5-24) is a DNA gene segment (not a protein or receptor) that encodes a diversity (D) region used in V(D)J recombination to generate the variable region of the immunoglobulin (antibody) heavy chain in B cells[2][3][4]. During B cell development, a single V (variable), D (diversity), and J (joining) gene segment are recombined to form the antibody's antigen recognition site, a process essential for broad immune recognition[1][2][3]. The IGHD5-24 gene segment is one of several D segments in the human IGH locus and is not expressed as a standalone protein nor does it act as a receptor or enzyme[4]. Some D segments are annotated as "non-functional" or pseudogenes, and IGHD5-24 is listed as "non-functional" in some sources[4], meaning it may not participate productively in recombination or translate into part of the antibody protein.
- Other names
- IGHD524IGHD5-24IGHD524 (repeats/misspellings)
02
Biological functions
Generation of antibody repertoire diversityImmune response (by enabling B cell diversity)
03
Disease associations
Other (no direct role as a disease target; indirectly essential for normal immune function and deficiencies in immunoglobulin gene rearrangement can lead to immunodeficiencies)
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