Immunoglobulin heavy variable (II)-78-1 (IGHVII-78-1)

Immunoglobulin heavy variable (II)-78-1 (IGHVII-78-1) is a gene segment belonging to the immunoglobulin heavy chain variable region gene family on human chromosome 14. According to multiple sources, this gene is classified as a pseudogene, meaning it does not encode a functional protein product and is not expressed as a productive immunoglobulin chain in the immune system[1][6][7]. Immunoglobulin variable (V) genes provide the diversity of the antigen-binding sites of antibodies, but pseudogenes in this family, including IGHVII-78-1, retain sequence similarity to functional V genes without being utilized in the immune response. Thus, IGHVII-78-1 is not considered a functional receptor, enzyme, transporter, or therapeutic target. Key supporting details and clarification: - IGHVII-78-1 is specifically annotated as a **pseudogene** and does not participate in producing functional immunoglobulin chains[1][6]. - The gene is a member of the immunoglobulin heavy variable (IGHV) region family, which is crucial for antibody diversity, but only functional IGHV gene segments contribute to the antigen-binding repertoire[1][4][7]. - No disease roles, drug interactions, or functions are attributed to this non-functional segment; it is not a therapeutic, diagnostic, or pharmacological target[1][6][7]. - The nomenclature “IGHVII-78-1”, “IGHV(II)-78-1”, “4-78.1P”, and similar, all refer to this same or highly related non-functional segment. - The presence of “pseudogene” (often abbreviated as "P") and lack of encoded protein, along with absence from immune repertoire studies, confirms its non-functional, non-target status[1][4][6][7]. This entry is, therefore, primarily a genomic annotation without functional, clinical, or therapeutic significance.

Other names

IGHV(II)-78-14-78.1PIGHVII781IGHVII-78-1