Immunoglobulin heavy variable 1-3 (IGHV1-3)

Immunoglobulin heavy variable 1-3 is a gene encoding the variable region of the heavy chain component of immunoglobulins (antibodies), which are key molecules of the adaptive immune system responsible for specific antigen recognition[1][6]. The product of IGHV1-3 forms part of the antigen binding site of immunoglobulin molecules—determining specificity and diversity of antibody responses via combination with corresponding light chain variable regions and through somatic mechanisms like V(D)J recombination and somatic hypermutation[1][7]. IGHV genes—including IGHV1-3—are not independent therapeutic targets or receptors but are structural genetic elements that contribute to the diversity and specificity of antibody-mediated immunity. Mutations or deletions in this and similar IGHV genes can impact immune repertoire and, in rare cases, be associated with immunological or developmental disorders[1][6].

Other names

IGHV1-3VI-3BIGHV13