Immunoglobulin heavy variable 1-46 (IGHV1-46)

Immunoglobulin heavy variable 1-46 (IGHV1-46) is a germline gene segment encoding part of the variable region of the heavy chain of human immunoglobulins (antibodies)[1][3][6]. The IGHV1-46 gene segment is involved in generating antibody diversity through V(D)J recombination during B cell development, contributing to the specificity of antigen binding and the humoral immune response[1][3][6]. Allelic variations in IGHV gene segments can influence the function and binding properties of antibodies and have been associated with variability in immune responses against infections such as SARS-CoV-2[2][4]. IGHV1-46 itself is not a therapeutic target; rather, it is a building block in antibody molecules, which may become therapeutically relevant if incorporated into a monoclonal antibody. IGHV gene usage is also important in studies of vaccine and infection responses but is not typically used directly as a therapeutic or diagnostic target[3][6].

Other names

Immunoglobulin heavy variable 1-46IGHV1-46Ig heavy chain V-I region DOTIg heavy chain V-I region HG3Ig heavy chain V-I region MotIGHV146