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Target intelligence / Profile preview
Immunoglobulin heavy variable 3-11 (IGHV3-11)
- Target
- IGHV3-11
- Molecular classification
- Immunoglobulin variable domain, Immunoglobulin gene family, Other (not an enzyme, transporter, receptor, or GPCR)
01
Overview
Immunoglobulin heavy variable 3-11 (IGHV3-11) encodes the variable region of the heavy chain of human immunoglobulins (antibodies), responsible for antigen binding as part of the adaptive immune response. The variable domains are created by somatic V(D)J recombination in B cells and contribute to the vast diversity of antibody antigen recognition. IGHV variable genes are essential for the specificity of the humoral response but are not themselves therapeutic targets or receptors. “Immunoglobulin heavy variable-11-1” does not exist as a recognized gene; the closest human match is IGHV3-11, a typical immunoglobulin variable region gene.
- Other names
- IGHV3-11Immunoglobulin heavy variable 3-11HV311_HUMAN (UniProt)
02
Mechanism of action
Not applicable. Ig variable domains are part of antibody recognition, not direct drug targets
03
Biological functions
Antigen bindingHumoral immune responseAntigen recognition
04
Disease associations
Cancer (certain lymphoid cancers may have clonal immunoglobulin rearrangements)Other (autoimmunity, e.g., potential genetic susceptibility)
05
Safety considerations
Not applicable for this segment itself; safety is relevant when antibodies (including engineered ones) are used therapeutically, not for native genetic segments
06
Biomarkers
No standardized use as therapeutic biomarkers; immunoglobulin gene rearrangement testing may be used for clonality in lymphoma diagnosis
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