Immunoglobulin heavy variable 3-13 (IGHV3-13)

Immunoglobulin heavy variable 3-13 (IGHV3-13) is a gene segment that encodes the variable region of the heavy chain of immunoglobulins (antibodies), specifically within subgroup 3 of human immunoglobulin heavy variable genes[1][3][8]. IGHV3-13 contributes to the diversity of antigen recognition by forming part of the antigen-binding site in antibodies, participating in the V-(D)-J rearrangement and somatic hypermutation processes in B lymphocytes, which are crucial for the functioning and adaptability of the humoral immune response[1]. IGHV3-13 itself is not a therapeutic receptor, enzyme, or direct drug target, but rather a genomic element enabling antibody diversity[1][2][4]. It does not interact directly with drugs nor is it typically used as a biomarker or safety concern; rather, it is one of many segments generating the immense variability required for effective immune surveillance[1][2][8].

Other names

IGHV3-13Ig heavy chain V-III region BROIGHV313Immunoglobulin heavy variable 3-13