Immunoglobulin heavy variable 3-15 (IGHV3-15)

Immunoglobulin heavy variable 3-15 (IGHV3-15) is a germline gene segment that codes for the variable region of the heavy chain in immunoglobulins (antibodies)[2][3][5]. Its sequence participates in the generation of antibody diversity through V(D)J recombination and somatic hypermutation within B lymphocytes[2][3][5]. The IGHV3-15 gene is expressed as part of the immunoglobulin complex and is located within the highly polymorphic IGH locus on chromosome 14[1][2]. During humoral immune responses, the variable domain encoded by IGHV3-15 pairs with the variable domain of the light chain to form the antigen binding site of antibodies, allowing precise recognition and neutralization of antigens[2][3][5]. Allelic variation within IGHV3-15 and other IGHV genes can affect binding affinity, specificity, and susceptibility to diseases, such as lymphoma or infections[1][4]. IGHV3-15 is thus a critical genetic determinant underlying the diversity and specificity of the human antibody repertoire, though not considered a drug target itself[2][3][5].

Other names

IGHV3-15IGHV315HV315immunoglobulin heavy chain variable regionimmunoglobulin heavy variable 3-15VH

None. As IGHV3-15 itself is incorporated into antibodies following genetic rearrangement, there is no mechanism of action for drugs against it as a molecular target.