Immunoglobulin heavy variable 3-25 (IGHV3-25)

Immunoglobulin heavy variable 3-25 is a gene segment located within the human immunoglobulin heavy chain locus, encoding part of the variable region of antibody heavy chains. This segment is one of many IGHV segments, contributing through recombination (with D and J segments) and hypermutation to the specificity and diversity of antibodies produced by B-lymphocytes. The variable region it encodes forms, together with the light chain variable region, the antigen-binding site of immunoglobulin molecules[1][2][5]. IGHV3-25 is mainly referenced in studies of antibody gene use, repertoire diversity, and immune response rather than as a direct drug or therapeutic target. If you are seeking information about a therapeutic antibody, those are the proteins encoded by assembled IGHV (including IGHV3-25) segments, not the gene segment itself. IGHV3-25 is not the name of an antibody, but the gene segment used in antibody construction.

Other names

3-25PIGHV325IGHV3-25