Immunoglobulin heavy variable 3-30 (IGHV3-30)

Immunoglobulin heavy variable 3-30 is a gene segment encoding the variable region of immunoglobulin heavy chains, which forms part of the antigen-binding site of antibodies. This variable region, together with the light chain variable region, determines the specificity and affinity of the antibody for antigens, playing a central role in the humoral immune response. These segments undergo somatic recombination (V-D-J rearrangement) during B cell development, contributing to the diversity of antibody repertoires needed for immune defense. IGHV3-30 is not itself a receptor, enzyme, or typical drug target but is instead a source of antibody gene diversity, essential for recognizing a wide variety of pathogens[1][4].

Other names

IGHV3-30Ig heavy chain V-III region BURIg heavy chain V-III region CAMIg heavy chain V-III region GAIg heavy chain V-III region NIEIGHV330VHimmunoglobulin heavy chain variable region