Immunoglobulin heavy variable 3-43 (IGHV3-43)

Immunoglobulin heavy variable 3-43 is a gene segment encoding the **variable domain** of the heavy chain in human immunoglobulins (antibodies)[1]. The protein, part of the immunoglobulin superfamily, contributes to antigen recognition by forming part of the antigen-binding site of antibodies, in conjunction with associated light chain variable domains[3]. The variable regions are generated through V-(D)-J recombination and provide the molecular diversity required for the adaptive humoral immune response[1][3]. The structure allows for high affinity binding to specific antigens, initiating B cell activation, clonal expansion, and differentiation into antibody-secreting plasma cells[1][3]. IGHV3-43 is one among many IGHV germline gene segments, and the usage—or mutation status—of IGHV genes (in general, not specifically IGHV3-43) can serve as a diagnostic and prognostic biomarker in diseases such as chronic lymphocytic leukemia[2]. IGHV3-43 itself is not a typical direct therapeutic target (i.e., not a receptor, enzyme, or transporter), but rather a segment encoding antibody diversity for immune recognition[1][3].

Other names

Immunoglobulin heavy variable 3-43IGHV3-43IGHV343VHimmunoglobulin heavy chain variable region