Immunoglobulin heavy variable 3-53 (IGHV3-53)

Immunoglobulin heavy variable 3-53 is a gene segment that encodes the variable region of the heavy chain of immunoglobulins (antibodies) in humans. The variable domain is responsible for antigen recognition, forming part of the antigen-binding site of immunoglobulin molecules. IGHV3-53 is a source of genetic diversity in the adaptive immune response and is especially notable as a common germline gene segment found in potent neutralizing antibodies against certain viral infections. It is not a classical therapeutic target like a receptor or enzyme, but it is essential for the specificity of antibody-based immune responses.

Other names

Immunoglobulin heavy variable 3-53IGHV3-53Ig heavy chain V-III region BUTIGHV353VHimmunoglobulin heavy chain variable region